In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing

In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing

Blog Article

Abstract Background Excessive oxidative stress at the wound sites always leads to a prolonged healing and even causes chronic inflammatory wounds.Therefore, antioxidative dressings with multiple features are desired to improve wound healing performance.Herein, we fabricated a ROS-scavenging hybrid hydrogel by incorporating mussel-inspired Wart Removers fullerene nanocomposites (C60@PDA) into gelatin methacryloyl (GelMA) hydrogel.Results The developed C60@PDA/GelMA hydrogel showed a sustainable free radical scavenging ability, and eliminated ROS to protect cells against external GREEK YOGURT STARTER oxidative stress damage.

Besides, the hydrogel presented favorable cytocompatibility, hemocompatibility, and antibacterial ability in vitro.Furthermore, in a mouse full-thickness wound defect model, the in situ forming hybrid hydrogel accelerated wound closure by 38.5% and 42.9% on day 3 and day 7 over the control.

Histological results demonstrated that hybrid hydrogels effectively enhanced wound healing on re-epithelialization, collagen deposition and angiogenesis.Conclusion Collectively, the C60@PDA/GelMA hydrogel could be a promising dressing for promoting cutaneous wound repair.